ISB 1442 is a First-In-Class 2+1 Biparatopic Bispecific BEAT® 2.0 Antibody Targeting CD38 and CD47
Data from Preclinical Models Suggest Higher Potency and Tumor Growth Inhibition for ISB 1442 Relative to Daratumumab
Enrollment in the First-in-Human ISB 1442 Trial is Expected to Start in Mid-2022
NEW YORK, NY, December 11, 2021 – Ichnos Sciences Inc., a global biotechnology company developing innovative biologics in oncology, today presented preclinical data that support the potential for ISB 1442, a first-in-class 2+1 biparatopic bispecific antibody that targets both CD38 and CD47, as a treatment for relapsed/refractory multiple myeloma and other CD38+ hematological malignancies. The data were presented today by Stefano Sammicheli, Ph.D., Director of Innate Cell Engagers, during an oral session at the 63rd American Society of Hematology (ASH) Annual Meeting.
ISB 1442 includes three arms in a 2+1 biparatopic BEAT® 2.0 bispecific format:
The data presented today demonstrate the potency and anti-tumor activity of ISB 1442 in multiple in vitro and in vivo tumor models relative to daratumumab and magrolimab. Specifically, the results show that:
“We are excited to present data on Ichnos’ first-in-class biparatopic CD38 x CD47 bispecific antibody at ASH,” said Mario Perro, Ph.D., Vice President Oncology, Interim Head of Discovery at Ichnos. “ISB 1442 has demonstrated high potency in multiple in vitro tumor models, including one that assessed multiple antibody-dependent mechanisms of actions simultaneously, and higher tumor growth inhibition in vivo. We believe that this asset has the potential to effectively treat patients with multiple myeloma who have relapsed or are refractory to daratumumab as well as other CD38 expressing hematological malignancies.”
“Today’s presentation represents another step forward as Ichnos works to bring this novel multispecific approach that co-targets CD38 and CD47 to patients with hematologic malignancies,” said Cyril Konto, M.D., President and Chief Executive Officer of Ichnos. “With its unique design and mechanisms of action, data suggest that ISB 1442 may enhance anti-tumor activity relative to approved anti-CD38 targeted therapies by overcoming primary and acquired tumor mechanisms of resistance. We look forward to submitting the IND to FDA in early 2022 and initiating our first-in-human clinical study in patients with relapsed/refractory multiple myeloma, acute myeloid leukemia and T-cell acute lymphoblastic leukemia in the middle of 2022.”
Ichnos continues to advance its pipeline of agents based on the proprietary BEAT® technology platform. Using this platform, Ichnos is exploring the full design space for treating cancer and engineering multispecific antibodies capable of simultaneously engaging tumor and immune cells.
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 Bispecific Engagement by Antibodies based on the T-cell receptor
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