Shifting Medicine Forward

Drawing on a deep understanding of the underlying causes, Ichnos Sciences is pursuing truly disease-centric therapies in oncology and autoimmune conditions. We strive to develop novel assets and find new answers to some of medicine’s greatest challenges. Because the world is waiting.

Our path toward disease-centric therapies

Oncology Pipeline
Products Description Preclinical Phase 1 Phase 2 Phase 3 Status
ISB 1342
CD38 x CD3 BEAT® 1.0 bispecific antibody
Relapsed/Refractory Multiple Myeloma (R/R MM); T-ALL under consideration
      Phase 1 Enrolling
ISB 1442
CD38 x CD47 BEAT® 2.0 bispecific antibody
R/R MM; AML and T-ALL under consideration
      PHASE 1 INITIATION
ISB 2001
BCMA x CD38 x CD3 TREAT™ trispecific antibody
R/R MM
      IND-Enabling Studies
Oncology Pipeline
Compound:
ISB 1342
Target:
CD38 x CD3 BEAT® 1.0 bispecific antibody
Indication:
Relapsed/Refractory Multiple Myeloma (R/R MM); T-ALL under consideration
Phase:
phase-1
Status:
Phase 1 Enrolling
Compound:
ISB 1442
Target:
CD38 x CD47 BEAT® 2.0 bispecific antibody
Indication:
R/R MM; AML and T-ALL under consideration
Phase:
phase-1
Status:
PHASE 1 INITIATION
Compound:
ISB 2001
Target:
BCMA x CD38 x CD3 TREAT™ trispecific antibody
Indication:
R/R MM
Phase:
preclinical
Status:
IND-Enabling Studies


BEAT®Bispecific Engagement by Antibodies based on the T-cell receptor
TREAT™: Trispecific Engagement by Antibodies based on the T-cell receptor

 
Autoimmune Disease
Products Description Preclinical Phase 1 Phase 2 Phase 3 Status
ISB 830 (telazorlimab) (Licensing discussions ongoing)
OX40 antagonist monoclonal antibody
Atopic Dermatitis (AD)*
      Phase 2b completed
ISB 880 (Licensed to Almirall S.A.)
IL-1RAP antagonist monoclonal antibody
Autoimmune Disease
      IND-Enabling Studies Completed
Autoimmune Disease
Compound:
ISB 830 (telazorlimab) (Licensing discussions ongoing)
Target:
OX40 antagonist monoclonal antibody
Indication:
Atopic Dermatitis (AD)*
Phase:
phase-2
Status:
Phase 2b completed
Compound:
ISB 880 (Licensed to Almirall S.A.)
Target:
IL-1RAP antagonist monoclonal antibody
Indication:
Autoimmune Disease
Phase:
preclinical
Status:
IND-Enabling Studies Completed

*A US IND for rheumatoid arthritis and other autoimmune indications is active.

Primary efficacy endpoint (EASI score, % change, baseline to week 16) met at two highest doses tested. Numerical improvements were seen for the two higher-dose arms (300 mg and 600 mg q 2 weeks) of telazorlimab compared to placebo in the secondary endpoints of EASI-75 and Investigator Global Assessment, but the differences were generally not statistically significantly different from placebo.

Note: Assets that were previously identified as GBR XXXX are now identified as ISB XXXX.

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